InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pinx1

Summary

InnateDB Protein

IDBP-173012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pinx1

Protein Name

PIN2/TERF1 interacting, telomerase inhibitor 1

Synonyms

2210403I16Rik; 2610028A01Rik; 67-11-3; AU024023; LPTS; LPTS1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022528

InnateDB Gene

IDBG-173010 (Pinx1)

Protein Structure

UniProt Annotation

Function

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0070034	telomeric RNA binding

Biological Process

GO:0007004	telomere maintenance via telomerase
GO:0007080	mitotic metaphase plate congression

Cellular Component

GO:0000228	nuclear chromosome
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000781	chromosome, telomeric region
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005819	spindle