Version 5.4
Mus musculus Protein: Asf1b
Summary
InnateDB Protein IDBP-173067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asf1b
Protein Name ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
Synonyms 1700003K02Rik; AA409591;
Species Mus musculus
Ensembl Protein ENSMUSP00000005607
InnateDB Gene IDBG-173065 (Asf1b)
Protein Structure
UniProt Annotation
Function Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. {ECO:0000269PubMed:17054786}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis. Restricted to premeiotic to meiotic stages during spermatogenesis. {ECO:0000269PubMed:12842904}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1914179
InterPro IPR006818 Histone chaperone, ASF1-like
PFAM PF04729
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAP7
PhosphoSite PhosphoSite-Q9DAP7
TrEMBL
UniProt Splice Variant
Entrez Gene 66929
UniGene Mm.29680
RefSeq NP_077146
MGI ID
MGI Symbol Asf1b
OMIM
CCDS CCDS22462
HPRD
IMGT
EMBL AK005646 AK019594 AK077005 AK077718 AK134906 AK150818 AK151951 AK165322 BC003428
GenPept AAH03428 BAB24166 BAB31809 BAC36561 BAC36978 BAE22334 BAE29881 BAE30824 BAE38137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca