InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uba2

Summary

InnateDB Protein

IDBP-173096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uba2

Protein Name

ubiquitin-like modifier activating enzyme 2

Synonyms

AA986091; Arx; Sae2; UBA1; Ubl1a2; Uble1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099807

InnateDB Gene

IDBG-173092 (Uba2)

Protein Structure

UniProt Annotation

Function

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention. {ECO:0000250}.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in testis. {ECO:0000269PubMed:11481243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016925	protein sumoylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1858313

InterPro

IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF10585

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z1F9

PhosphoSite