Version 5.4
Homo sapiens Protein: SHPK
Summary
InnateDB Protein IDBP-17310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHPK
Protein Name sedoheptulokinase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000225519
InnateDB Gene IDBG-17308 (SHPK)
Protein Structure
UniProt Annotation
Function Acts as a modulator of macrophage activation through control of glucose metabolism. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain. {ECO:0000269PubMed:10673275}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0050277 sedoheptulokinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0016310 phosphorylation
GO:0035963 cellular response to interleukin-13
GO:0043030 regulation of macrophage activation
GO:0050727 regulation of inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR018484 Carbohydrate kinase, FGGY, N-terminal
PFAM PF00370
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHJ6
PhosphoSite PhosphoSite-Q9UHJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 23729
UniGene Hs.579217
RefSeq NP_037408
HUGO HGNC:1492
OMIM 605060
CCDS CCDS11030
HPRD 05451
IMGT
EMBL AC027796 AF163573 AF168787 AK312428 AL832420 BC020543 CH471108
GenPept AAF24936 AAF43103 AAH20543 BAG35337 CAH10646 EAW90501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca