InnateDB Protein
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IDBP-173155.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Efna2
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Protein Name
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ephrin A2
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Synonyms
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CEK7L; Elf1; Epl6; Eplg6; Lerk6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000003154
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InnateDB Gene
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IDBG-173153 (Efna2)
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Protein Structure
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Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269PubMed:19299512, ECO:0000269PubMed:9053851}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:102707
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InterPro |
IPR001799
Ephrin
IPR008972
Cupredoxin
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PFAM |
PF00812
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PRINTS |
PR01347
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P52801
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13637
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UniGene |
Mm.407192
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RefSeq |
NP_031935
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MGI ID |
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MGI Symbol |
Efna2
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OMIM |
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CCDS |
CCDS24013
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HPRD |
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IMGT |
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EMBL |
BC048697
U14752
U14941
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GenPept |
AAA53636
AAA68520
AAH48697
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