InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGFLAM

Summary

InnateDB Protein

IDBP-17325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGFLAM

Protein Name

EGF-like, fibronectin type III and laminin G domains

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346964

InnateDB Gene

IDBG-17319 (EGFLAM)

Protein Structure

UniProt Annotation

Function

Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding

Biological Process

GO:0010811	positive regulation of cell-substrate adhesion
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0030054	cell junction
GO:0031012	extracellular matrix
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00054
PF02210
PF07645
PF00041
PF01108

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q63HQ2