InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Orc1

Summary

InnateDB Protein

IDBP-173267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Orc1

Protein Name

origin recognition complex, subunit 1

Synonyms

AA545195; MmORC1; Orc1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099805

InnateDB Gene

IDBG-173263 (Orc1)

Protein Structure

UniProt Annotation

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260

DNA replication

Cellular Component

GO:0000808	origin recognition complex
GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1328337

InterPro

IPR001025 Bromo adjacent homology (BAH) domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR015163 CDC6, C-terminal domain
IPR018647 Domain of unknown function DUF2075
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01426
PF00004
PF07724
PF13304
PF09079
PF09848

PRINTS

PIRSF

SMART

SM00439
SM00382
SM01074

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z1N2