InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il27ra

Summary

InnateDB Protein

IDBP-173275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il27ra

Protein Name

interleukin 27 receptor, alpha

Synonyms

CRL1; IL-27R; Tccr; WSX-1; Wsx1; zcytor1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005601

InnateDB Gene

IDBG-173273 (Il27ra)

Protein Structure

UniProt Annotation

Function

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in CD4+ and CD8+ T-cells, B-cells, natural killer cells and macrophages. Highest levels in CD4+ T- cells and natural killer cells. Expression highest in Th0 cells. {ECO:0000269PubMed:11057672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045509	interleukin-27 receptor activity

Biological Process

GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002829	negative regulation of type 2 immune response
GO:0032729	positive regulation of interferon-gamma production
GO:0048302	regulation of isotype switching to IgG isotypes
GO:0050830	defense response to Gram-positive bacterium
GO:0070106	interleukin-27-mediated signaling pathway