Mus musculus Protein: Glra4
Summary
InnateDB Protein IDBP-173307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glra4
Protein Name glycine receptor, alpha 4 subunit
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000018739
InnateDB Gene IDBG-173305 (Glra4)
Protein Structure
UniProt Annotation
Function The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). May play a role in the maturation of reproductive organs. {ECO:0000269PubMed:10762330}.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0016594 glycine binding
GO:0022824 transmitter-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:95750
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01673
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61603
PhosphoSite PhosphoSite-
TrEMBL Q2TB05
UniProt Splice Variant
Entrez Gene 14657
UniGene Mm.215168
RefSeq NP_034427
MGI ID
MGI Symbol Glra4
OMIM
CCDS CCDS53195
HPRD
IMGT
EMBL AF462147 AL671887 BC110630 CH466616 DQ109809 X75850 X75851 X75852 X75853
GenPept AAI10631 AAL69899 AAZ17380 CAA53468 CAM17223 EDL23874