Version 5.4
Mus musculus Protein: Rln3
Summary
InnateDB Protein IDBP-173347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rln3
Protein Name relaxin 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051392
InnateDB Gene IDBG-173345 (Rln3)
Protein Structure
UniProt Annotation
Function May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary. {ECO:0000269PubMed:11689565}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0030819 positive regulation of cAMP biosynthetic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2158015
InterPro IPR016179 Insulin-like
IPR022352 Insulin family
PFAM PF00049
PRINTS PR00276
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CHK2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 212108
UniGene Mm.261583
RefSeq NP_775276
MGI ID
MGI Symbol Rln3
OMIM
CCDS CCDS22466
HPRD
IMGT
EMBL AB076565
GenPept BAC53760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca