InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfx1

Summary

InnateDB Protein

IDBP-173388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfx1

Protein Name

regulatory factor X, 1 (influences HLA class II expression)

Synonyms

AI047719; AI385641;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005600

InnateDB Gene

IDBG-173386 (Rfx1)

Protein Structure

UniProt Annotation

Function

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00858}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:105982

InterPro

IPR003150 DNA-binding RFX-type winged-helix domain
IPR007668 RFX1 transcription activation region

PFAM

PF02257
PF04589

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48377

PhosphoSite

PhosphoSite-P48377

TrEMBL

Q8BYY2

UniProt Splice Variant

Entrez Gene

19724

UniGene

Mm.7892

RefSeq

NP_033081

MGI ID

MGI Symbol

Rfx1

OMIM

CCDS

CCDS22468

HPRD

IMGT

EMBL

AK037226 BC057018 CH466525 X76088

GenPept

AAH57018 BAC29765 CAA53702 EDL10930