Version 5.4
Mus musculus Protein: Ckb
Summary
InnateDB Protein IDBP-173413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ckb
Protein Name creatine kinase, brain
Synonyms B-CK; Bck; Ck-3; Ck3; Ckbb;
Species Mus musculus
Ensembl Protein ENSMUSP00000001304
InnateDB Gene IDBG-173411 (Ckb)
Protein Structure
UniProt Annotation
Function Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0007420 brain development
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0030644 cellular chloride ion homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88407
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
IPR022414 ATP:guanido phosphotransferase, catalytic domain
PFAM PF02807
PF00217
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q04447
PhosphoSite PhosphoSite-Q04447
TrEMBL
UniProt Splice Variant
Entrez Gene 12709
UniGene Mm.16831
RefSeq NP_067248
MGI ID
MGI Symbol Ckb
OMIM
CCDS CCDS26183
HPRD
IMGT
EMBL AK002467 AK014299 AK148885 AK152388 AK153484 AK161990 AK166980 AK167034 BC015271 BC106109 L09069 M74149 X04591
GenPept AAA37455 AAA37462 AAH15271 AAI06110 BAB22121 BAB29254 BAE28690 BAE31176 BAE32032 BAE36669 BAE39162 BAE39205 CAA28259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca