Version 5.4
Mus musculus Protein: Cc2d1b
Summary
InnateDB Protein IDBP-173426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cc2d1b
Protein Name coiled-coil and C2 domain containing 1B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000030320
InnateDB Gene IDBG-173424 (Cc2d1b)
Protein Structure
UniProt Annotation
Function Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269PubMed:21155902}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21155902}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2443076
InterPro IPR000008 C2 domain
IPR006608 Domain of unknown function DM14
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
SM00685
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BRN9
PhosphoSite PhosphoSite-Q8BRN9
TrEMBL
UniProt Splice Variant
Entrez Gene 319965
UniGene Mm.151129
RefSeq NP_796019
MGI ID
MGI Symbol Cc2d1b
OMIM
CCDS CCDS18454
HPRD
IMGT
EMBL AK043839 AK146601 AK173271 AL626783 BC125517 BC137743
GenPept AAI25518 AAI37744 BAC31675 BAD32549 BAE27295 CAM23502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca