Mus musculus Protein: Chl1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-173448.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Chl1 | ||||||||||||||||||||||
Protein Name | cell adhesion molecule with homology to L1CAM | ||||||||||||||||||||||
Synonyms | A530023M13Rik; AI465420; CALL; LICAM2; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000063933 | ||||||||||||||||||||||
InnateDB Gene | IDBG-173444 (Chl1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. {ECO:0000269PubMed:10022583, ECO:0000269PubMed:10103075, ECO:0000269PubMed:12391163, ECO:0000269PubMed:12721290, ECO:0000269PubMed:12812975, ECO:0000269PubMed:14659567, ECO:0000269PubMed:14761956, ECO:0000269PubMed:15504324, ECO:0000269PubMed:16623841}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Note=Soluble forms produced by cleavage/shedding also exist.Processed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in the brain, in the cerebellum and in the spinal cord. Detected in the retina and the optic nerve. Expressed in neurons and glial cells in the central nervous system and by Schwann cells in the peripheral nervous system. {ECO:0000269PubMed:10103075, ECO:0000269PubMed:15504324, ECO:0000269PubMed:8921253}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1098266 | ||||||||||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR003961 Fibronectin, type III IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin |
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PFAM |
PF00041
PF01108 PF07679 PF07686 PF00047 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00408
SM00409 SM00060 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P70232 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P70232 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 12661 | ||||||||||||||||||||||
UniGene | Mm.251288 | ||||||||||||||||||||||
RefSeq | NP_031723 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Chl1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS39582 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC153595 AC153598 AC161824 AJ319655 AJ319656 AJ319657 AK040765 AK048639 AK053039 BC131670 BC131671 CH466523 X94310 | ||||||||||||||||||||||
GenPept | AAI31671 AAI31672 BAC30699 BAC33405 BAC35247 CAA63972 CAC88131 EDK99388 | ||||||||||||||||||||||