InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr2e3

Summary

InnateDB Protein

IDBP-173542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr2e3

Protein Name

nuclear receptor subfamily 2, group E, member 3

Synonyms

A930035N01Rik; PNR; rd7; RNR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034831

InnateDB Gene

IDBG-173540 (Nr2e3)

Protein Structure

UniProt Annotation

Function

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. {ECO:0000269PubMed:15190009, ECO:0000269PubMed:15634773, ECO:0000269PubMed:19186166, ECO:0000269PubMed:21408158}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:15190009, ECO:0000269PubMed:19186166}.

Disease Associations

Tissue Specificity

Retina. Rod-specific. Expressed in the outer nuclear lyer of the mature retina. {ECO:0000269PubMed:10611353, ECO:0000269PubMed:10805811, ECO:0000269PubMed:15190009, ECO:0000269PubMed:15634773, ECO:0000269PubMed:21408158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0030522	intracellular receptor signaling pathway
GO:0042462	eye photoreceptor cell development
GO:0043401	steroid hormone mediated signaling pathway
GO:0045872	positive regulation of rhodopsin gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:1346317

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01282

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt