InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: As3mt

Summary

InnateDB Protein

IDBP-173548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

As3mt

Protein Name

arsenic (+3 oxidation state) methyltransferase

Synonyms

2310045H08Rik; Cyt19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003655

InnateDB Gene

IDBG-173546 (As3mt)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0030791	arsenite methyltransferase activity
GO:0030792	methylarsonite methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0009404	toxin metabolic process
GO:0018872	arsonoacetate metabolic process
GO:0032259	methylation
GO:0046685	response to arsenic-containing substance

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1929882

InterPro

IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01135
PF01209
PF08241
PF08242

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91WU5

PhosphoSite