InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adm2

Summary

InnateDB Protein

IDBP-173573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adm2

Protein Name

adrenomedullin 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064761

InnateDB Gene

IDBG-173571 (Adm2)

Protein Structure

UniProt Annotation

Function

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. {ECO:0000269PubMed:14615490, ECO:0000269PubMed:14706825}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior lobe. {ECO:0000269PubMed:14615490, ECO:0000269PubMed:14706825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0032403	protein complex binding

Biological Process

GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007586	digestion
GO:0007631	feeding behavior
GO:0010628	positive regulation of gene expression
GO:0045766	positive regulation of angiogenesis
GO:0045776	negative regulation of blood pressure