InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chst8

Summary

InnateDB Protein

IDBP-173579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chst8

Protein Name

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

Synonyms

1500011J21Rik; AI426009;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077752

InnateDB Gene

IDBG-173577 (Chst8)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in brain. Weakly expressed in lung and kidney. Weakly expressed in pituitary. {ECO:0000269PubMed:12944377}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0006790	sulfur compound metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0016486	peptide hormone processing
GO:0030166	proteoglycan biosynthetic process
GO:0042446	hormone biosynthetic process