Mus musculus Protein: Cntn6
Summary
InnateDB Protein IDBP-173672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cntn6
Protein Name contactin 6
Synonyms NB-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000086623
InnateDB Gene IDBG-173670 (Cntn6)
Protein Structure
UniProt Annotation
Function Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination. {ECO:0000250, ECO:0000269PubMed:12884264}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum. {ECO:0000269PubMed:10717476}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:1858223
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF00041
PF01108
PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMB8
PhosphoSite PhosphoSite-
TrEMBL E0CY26
UniProt Splice Variant
Entrez Gene 53870
UniGene Mm.321671
RefSeq NP_059079
MGI ID
MGI Symbol Cntn6
OMIM
CCDS CCDS20394
HPRD
IMGT
EMBL AB032602 AC116110 AC117728 AC153023 AC153990 AK052972 BC076594
GenPept AAH76594 BAA92367 BAC35227