Version 5.4
Mus musculus Protein: Cc2d1a
Summary
InnateDB Protein IDBP-173675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cc2d1a
Protein Name coiled-coil and C2 domain containing 1A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046449
InnateDB Gene IDBG-173673 (Cc2d1a)
Protein Structure
UniProt Annotation
Function Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. {ECO:0000269PubMed:12917378, ECO:0000269PubMed:14756806, ECO:0000269PubMed:21273312}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in brain, expression is enriched in the gray matter and strongest in the olfactory bulb. {ECO:0000269PubMed:16033914, ECO:0000269PubMed:21273312}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2384831
InterPro IPR000008 C2 domain
IPR006608 Domain of unknown function DM14
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
SM00685
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1A6
PhosphoSite PhosphoSite-Q8K1A6
TrEMBL
UniProt Splice Variant
Entrez Gene 212139
UniGene Mm.41424
RefSeq NP_666082
MGI ID
MGI Symbol Cc2d1a
OMIM
CCDS CCDS40407
HPRD
IMGT
EMBL BC016188 BC027028 DQ329239
GenPept AAH16188 AAH27028 ABC56419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca