Version 5.4
| Mus musculus Protein: Col4a4 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-173689.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Col4a4 | ||||||||
| Protein Name | collagen, type IV, alpha 4 | ||||||||
| Synonyms | [a]4(IV); E130010M05Rik; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000084282 | ||||||||
| InnateDB Gene | IDBG-173685 (Col4a4) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000250UniProtKB:P53420, ECO:0000269PubMed:10639489, ECO:0000269PubMed:7962065}. | ||||||||
| Subcellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255PROSITE-ProRule:PRU00736, ECO:0000269PubMed:7962065}. Note=Colocalizes with COL4A3 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250UniProtKB:P53420, ECO:0000269PubMed:7962065}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highly expressed in kidney and lung. Detected at lower levels in heart, muscle and skin. {ECO:0000269PubMed:7962065}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:104687 | ||||||||
| InterPro |
IPR001442
Collagen IV, non-collagenous IPR008160 Collagen triple helix repeat IPR016187 C-type lectin fold |
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| PFAM |
PF01413
PF01391 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00111
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9QZR9 | ||||||||
| PhosphoSite | PhosphoSite-Q9QZR9 | ||||||||
| TrEMBL | Q3UQE0 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 12829 | ||||||||
| UniGene | Mm.40253 | ||||||||
| RefSeq | NP_031761 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Col4a4 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS35630 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF169388 AK142553 BC117709 Z35167 | ||||||||
| GenPept | AAD50450 AAI17710 BAE25102 CAA84530 | ||||||||