InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmd14

Summary

InnateDB Protein

IDBP-173798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmd14

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

Synonyms

2610312C03Rik; 3200001M20Rik; AA986732; Pad1; Poh1; rpm11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028278

InnateDB Gene

IDBG-173796 (Psmd14)

Protein Structure

UniProt Annotation

Function

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding
GO:0061133	endopeptidase activator activity
GO:0070628	proteasome binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006508	proteolysis
GO:0010950	positive regulation of endopeptidase activity
GO:0061136	regulation of proteasomal protein catabolic process
GO:0070536	protein K63-linked deubiquitination

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0008541	proteasome regulatory particle, lid subcomplex
GO:0022624	proteasome accessory complex
GO:0070062	extracellular vesicular exosome