Version 5.4
Mus musculus Protein: Zfyve21
Summary
InnateDB Protein IDBP-173809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfyve21
Protein Name zinc finger, FYVE domain containing 21
Synonyms 1110013H04Rik; AW558780; C85416;
Species Mus musculus
Ensembl Protein ENSMUSP00000021714
InnateDB Gene IDBG-173807 (Zfyve21)
Protein Structure
UniProt Annotation
Function Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, focal adhesion. Cytoplasmic vesicle {ECO:0000250}. Endosome {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:20439989}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005768 endosome
GO:0005925 focal adhesion
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:1915770
InterPro IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCM3
PhosphoSite PhosphoSite-Q8VCM3
TrEMBL
UniProt Splice Variant
Entrez Gene 68520
UniGene
RefSeq NP_081028
MGI ID
MGI Symbol Zfyve21
OMIM
CCDS CCDS56865
HPRD
IMGT
EMBL AK003661 AK155300 AK171099 BC019521 BC132248 BC132250
GenPept AAH19521 AAI32249 AAI32251 BAB22923 BAE33175 BAE42248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca