InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aggf1

Summary

InnateDB Protein

IDBP-173832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aggf1

Protein Name

angiogenic factor with G patch and FHA domains 1

Synonyms

2010009L17Rik; 2310029P06Rik; AW112072; Peg3; VG5Q;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022189

InnateDB Gene

IDBG-173830 (Aggf1)

Protein Structure

UniProt Annotation

Function

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0007155	cell adhesion
GO:0030154	cell differentiation
GO:0045766	positive regulation of angiogenesis