InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r13b

Summary

InnateDB Protein

IDBP-173856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r13b

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 13B

Synonyms

AI449786; ASPP1; AW545810; p85; Tp53bp2; Trp53bp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062464

InnateDB Gene

IDBG-173854 (Ppp1r13b)

Protein Structure

UniProt Annotation

Function

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic (By similarity). Some fraction is nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0045786	negative regulation of cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1336199

InterPro

IPR001452 SH3 domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain
IPR029071 Ubiquitin-related domain

PFAM