Version 5.4
Mus musculus Protein: Larp6
Summary
InnateDB Protein IDBP-173870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Larp6
Protein Name La ribonucleoprotein domain family, member 6
Synonyms 5430431G03Rik; Achn; AI552438;
Species Mus musculus
Ensembl Protein ENSMUSP00000040309
InnateDB Gene IDBG-173868 (Larp6)
Protein Structure
UniProt Annotation
Function Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in numerous tissues. Highest expression in heart and brain, intermediate in kidney, skeletal muscle and testis, lowest expression in testis (at protein level). {ECO:0000269PubMed:17383118}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
Biological Process
GO:0006396 RNA processing
GO:0006417 regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:1914807
InterPro IPR002344 Lupus La protein
IPR006630 RNA-binding protein Lupus La
PFAM PF05383
PRINTS PR00302
PIRSF
SMART SM00715
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BN59
PhosphoSite PhosphoSite-Q8BN59
TrEMBL Q8CBL4
UniProt Splice Variant
Entrez Gene 67557
UniGene Mm.44546
RefSeq NP_080511
MGI ID
MGI Symbol Larp6
OMIM
CCDS CCDS23258
HPRD
IMGT
EMBL AK017372 AK020966 AK035809 AK039614 AK042616 AK087521 BC090615
GenPept AAH90615 BAB30713 BAB32263 BAC29193 BAC30400 BAC31306 BAC39909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca