InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crhbp

Summary

InnateDB Protein

IDBP-173914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crhbp

Protein Name

corticotropin releasing hormone binding protein

Synonyms

CRH-BP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042578

InnateDB Gene

IDBG-173912 (Crhbp)

Protein Structure

UniProt Annotation

Function

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042277	peptide binding
GO:0051424	corticotropin-releasing hormone binding

Biological Process

GO:0001963	synaptic transmission, dopaminergic
GO:0002125	maternal aggressive behavior
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0007610	behavior
GO:0009755	hormone-mediated signaling pathway
GO:0033554	cellular response to stress
GO:0035690	cellular response to drug
GO:0035865	cellular response to potassium ion
GO:0042445	hormone metabolic process
GO:0045055	regulated secretory pathway
GO:0048149	behavioral response to ethanol
GO:0050795	regulation of behavior
GO:0051459	regulation of corticotropin secretion
GO:0051460	negative regulation of corticotropin secretion
GO:0071277	cellular response to calcium ion
GO:0071314	cellular response to cocaine
GO:0071320	cellular response to cAMP
GO:0071356	cellular response to tumor necrosis factor
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0097211	cellular response to gonadotropin-releasing hormone
GO:1900011	negative regulation of corticotropin-releasing hormone receptor activity
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005767	secondary lysosome
GO:0005771	multivesicular body
GO:0005874	microtubule
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0031045	dense core granule
GO:0043196	varicosity
GO:0043204	perikaryon
GO:0043679	axon terminus