InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nanos3

Summary

InnateDB Protein

IDBP-173931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nanos3

Protein Name

nanos homolog 3 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067385

InnateDB Gene

IDBG-173929 (Nanos3)

Protein Structure

UniProt Annotation

Function

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269PubMed:12947200, ECO:0000269PubMed:17138666, ECO:0000269PubMed:18089289, ECO:0000269PubMed:18436203}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co- localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co- localizes with DCP1A in the P-body.

Disease Associations

Tissue Specificity

Expressed in undifferentiated spermatogonial cells. {ECO:0000269PubMed:12947200, ECO:0000269PubMed:18089289, ECO:0000269PubMed:19861488}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006417	regulation of translation
GO:0007275	multicellular organismal development
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0048477	oogenesis
GO:0051726	regulation of cell cycle
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0048471	perinuclear region of cytoplasm