Version 5.4
Mus musculus Protein: Rhpn2
Summary
InnateDB Protein IDBP-173961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhpn2
Protein Name rhophilin, Rho GTPase binding protein 2
Synonyms 1300002E07Rik; AA536890; C85860; D7Ertd784e;
Species Mus musculus
Ensembl Protein ENSMUSP00000032705
InnateDB Gene IDBG-173957 (Rhpn2)
Protein Structure
UniProt Annotation
Function Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1289234
InterPro IPR001478 PDZ domain
IPR004328 BRO1 domain
IPR011072 HR1 rho-binding repeat
PFAM PF00595
PF13180
PF03097
PF02185
PRINTS
PIRSF
SMART SM00228
SM01041
SM00742
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BWR8
PhosphoSite PhosphoSite-Q8BWR8
TrEMBL
UniProt Splice Variant
Entrez Gene 52428
UniGene Mm.286600
RefSeq NP_082173
MGI ID 1VAE
MGI Symbol Rhpn2
OMIM
CCDS CCDS21148
HPRD
IMGT
EMBL AK004849 AK050214
GenPept BAB23615 BAC34127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca