InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdrd9

Summary

InnateDB Protein

IDBP-174057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdrd9

Protein Name

tudor domain containing 9

Synonyms

4930441E05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078022

InnateDB Gene

IDBG-174055 (Tdrd9)

Protein Structure

UniProt Annotation

Function

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process. {ECO:0000269PubMed:20059948}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies.

Disease Associations

Tissue Specificity

Predominantly expressed in reproductive organs. Detected in mitotic spermatogonia, meiotic spermatocytes (predominantly at the pachytene stage), haploid spermatids in the testis, and in growing oocytes in the ovary (at protein level). {ECO:0000269PubMed:20059948}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007140	male meiosis
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation

Cellular Component

GO:0005634	nucleus
GO:0071547	piP-body

Protein Structure and Domains

PDB ID

MGI:1921941

InterPro

IPR001650 Helicase, C-terminal
IPR002999 Tudor domain
IPR007502 Helicase-associated domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00567
PF04408
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00333
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14BI7