InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc42se2

Summary

InnateDB Protein

IDBP-174074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc42se2

Protein Name

CDC42 small effector 2

Synonyms

2810404F18Rik; AA408783; AA536669; SPEC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070725

InnateDB Gene

IDBG-174072 (Cdc42se2)

Protein Structure

UniProt Annotation

Function

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in spleen, thymus and lung (at protein level). {ECO:0000269PubMed:15840583}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006909	phagocytosis
GO:0008360	regulation of cell shape
GO:0009966	regulation of signal transduction

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome