InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C230052I12Rik

Summary

InnateDB Protein

IDBP-174100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C230052I12Rik

Protein Name

RIKEN cDNA C230052I12 gene

Synonyms

AW124591; AW538696; Faap24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032704

InnateDB Gene

IDBG-174098 (C230052I12Rik)

Protein Structure

UniProt Annotation

Function

Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0043231	intracellular membrane-bounded organelle
GO:0043240	Fanconi anaemia nuclear complex

Protein Structure and Domains

PDB ID

MGI:2142208

InterPro

IPR010994 RuvA domain 2-like

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHL6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

101831

UniGene

Mm.389855

RefSeq

NP_848758

MGI ID

MGI Symbol

C230052I12Rik

OMIM

CCDS

CCDS21149

HPRD

IMGT

EMBL

AK031566 AK040248 AK082457 AK166481 BC096687

GenPept

AAH96687 BAC27452 BAC30550 BAC38495 BAE38800