InnateDB Protein
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IDBP-174154.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Krtap19-4
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Protein Name
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keratin associated protein 16-4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000056250
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InnateDB Gene
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IDBG-174152 (Krtap19-4)
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Protein Structure
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Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). {ECO:0000269PubMed:15385554}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2157757
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InterPro |
IPR021743
Keratin-associated protein, type6/8/16/19/20
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PFAM |
PF11759
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q925H7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
170654
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UniGene |
Mm.196689
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RefSeq |
NP_570943
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MGI ID |
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MGI Symbol |
Krtap19-4
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OMIM |
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CCDS |
CCDS37387
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HPRD |
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IMGT |
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EMBL |
AF345294
BC116200
BC116201
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GenPept |
AAI16201
AAI16202
AAK52892
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