InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chkb

Summary

InnateDB Protein

IDBP-174206.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chkb

Protein Name

choline kinase beta

Synonyms

Chetk; Chkl; Ck; Ck/Ek; Ck/Ek-beta; Ckb; Ckekb; Ek;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023289

InnateDB Gene

IDBG-174075 (Chkb)

Protein Structure

UniProt Annotation

Function

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Note=Defects in Chkb are a cause of rostrocaudal muscular dystrophy (rmd). The disease is characterized by rapidly progressive muscular dystrophy and neonatal forelimb bone deformity. The dystrophy is only evident in skeletal muscle tissues in an unusual rostral-to-caudal gradient. {ECO:0000269PubMed:16371353}.

Tissue Specificity

Expressed ubiquitously with the highest level in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004103	choline kinase activity
GO:0004305	ethanolamine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0007517	muscle organ development
GO:0016310	phosphorylation