Version 5.4
Mus musculus Protein: Gca
Summary
InnateDB Protein IDBP-174249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gca
Protein Name grancalcin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000028257
InnateDB Gene IDBG-174247 (Gca)
Protein Structure
UniProt Annotation
Function Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. {ECO:0000269PubMed:16934789}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1918521
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VC88
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227960
UniGene Mm.395919
RefSeq NP_663498
MGI ID
MGI Symbol Gca
OMIM
CCDS CCDS16069
HPRD
IMGT
EMBL AB088388 AF518325 AK033740 AK046347 AK049317 AK050540 AK078915 BC021450
GenPept AAH21450 AAM66720 BAC07231 BAC28458 BAC32686 BAC33679 BAC34315 BAC37457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca