Version 5.4
Mus musculus Protein: Pnoc
Summary
InnateDB Protein IDBP-174255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnoc
Protein Name prepronociceptin
Synonyms N/OFQ; N23K; Npnc1; OFQ/N;
Species Mus musculus
Ensembl Protein ENSMUSP00000054210
InnateDB Gene IDBG-174253 (Pnoc)
Protein Structure
UniProt Annotation
Function Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly, nociceptin induces hyperalgesia and decreases locomotor activity.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Brain and spinal cord. Low levels in kidney and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005515 protein binding
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:105308
InterPro IPR002367 Nociceptin
IPR006024 Opioid neuropeptide precursor
PFAM PF01160
PRINTS PR01031
PR01028
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64387
PhosphoSite PhosphoSite-Q64387
TrEMBL Q99NQ2
UniProt Splice Variant
Entrez Gene 18155
UniGene Mm.486163
RefSeq NP_035062
MGI ID
MGI Symbol Pnoc
OMIM
CCDS CCDS27213
HPRD
IMGT
EMBL AK045893 AY011825 BC119372 D50055 D50056 D82866 KF006993 U44027 X97371 X97372 X97373
GenPept AAC52581 AAG38274 AAI19373 AGT80622 BAA08773 BAA08774 BAA11614 BAC32523 CAA66041 CAA66042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca