InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krtap6-5

Summary

InnateDB Protein

IDBP-174258.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krtap6-5

Protein Name

keratin associated protein 16-8

Synonyms

1110002D05Rik; Krtap16-8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074211

InnateDB Gene

IDBG-174256 (Krtap6-5)

Protein Structure

UniProt Annotation

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.

Subcellular Localization

Disease Associations

Tissue Specificity

Strong expression in narrowly defined pattern restricted to the lower and middle cortical regions of the hair shaft in both developing and cycling hair. During hair follicle regression (catagen), expression levels decrease until expression is no longer detectable in follicles at resting stage (telogen). {ECO:0000269PubMed:15385554, ECO:0000269PubMed:15489334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005882	intermediate filament

Protein Structure and Domains

PDB ID

MGI:1915734

InterPro

IPR021743 Keratin-associated protein, type6/8/16/19/20

PFAM

PF11759

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q925H3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

68484

UniGene

Mm.46209

RefSeq

NP_570926

MGI ID

MGI Symbol

Krtap6-5

OMIM

CCDS

CCDS37390

HPRD

IMGT

EMBL

AF345298 AK003281 BC132612

GenPept

AAI32613 AAK52896 BAC25027