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InnateDB Protein
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IDBP-174275.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plekho1
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Protein Name
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pleckstrin homology domain containing, family O member 1
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Synonyms
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2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000015889
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InnateDB Gene
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IDBG-174273 (Plekho1)
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Protein Structure
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| Function |
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Membrane {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
8
[view]
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| Protein-Protein |
8
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
14 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1914470
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| InterPro |
IPR001849
Pleckstrin homology domain
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| PFAM |
PF00169
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| PRINTS |
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| PIRSF |
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| SMART |
SM00233
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9JIY0
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| PhosphoSite |
PhosphoSite-Q9JIY0
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
67220
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| UniGene |
Mm.458480
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| RefSeq |
NP_075809
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| MGI ID |
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| MGI Symbol |
Plekho1
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| OMIM |
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| CCDS |
CCDS17627
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| HPRD |
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| IMGT |
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| EMBL |
AF168675
AK014374
AK170025
AK170922
BC117003
BC125441
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| GenPept |
AAF89643
AAI17004
AAI25442
BAB29306
BAE41517
BAE42115
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Version 5.4