InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapk8ip2

Summary

InnateDB Protein

IDBP-174301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk8ip2

Protein Name

mitogen-activated protein kinase 8 interacting protein 2

Synonyms

3230402N03Rik; AI847694; AW049958; IB2; Jip2; R75148;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023291

InnateDB Gene

IDBG-174299 (Mapk8ip2)

Protein Structure

UniProt Annotation

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Note=Accumulates in cell surface projections. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Expressed in all neurons. Also expressed in testis, primarily in the epididymal epidermis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0032403	protein complex binding

Biological Process

GO:0000165	MAPK cascade
GO:0001662	behavioral fear response
GO:0007254	JNK cascade
GO:0007617	mating behavior
GO:0010469	regulation of receptor activity
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0035176	social behavior
GO:0045860	positive regulation of protein kinase activity
GO:0046328	regulation of JNK cascade
GO:0046958	nonassociative learning
GO:0048813	dendrite morphogenesis
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity