InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Onecut3

Summary

InnateDB Protein

IDBP-174307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Onecut3

Protein Name

one cut domain, family member 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053288

InnateDB Gene

IDBG-174305 (Onecut3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. {ECO:0000269PubMed:11944891}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00374, ECO:0000269PubMed:15381696}.

Disease Associations

Tissue Specificity

Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum. {ECO:0000269PubMed:11944891}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0031018	endocrine pancreas development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter