Version 5.4
Mus musculus Protein: Ripply1
Summary
InnateDB Protein IDBP-174376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ripply1
Protein Name ripply1 homolog (zebrafish)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000098778
InnateDB Gene IDBG-174374 (Ripply1)
Protein Structure
UniProt Annotation
Function Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). {ECO:0000250UniProtKB:Q2WG80}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q2WG80}.
Disease Associations
Tissue Specificity Expressed in the anterior presomitic mesoderm and somites of stage E9.5 embryos. Also expressed in tongue, diaphragm and intercostal muscles at E16.5. {ECO:0000269PubMed:16326386}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001757 somite specification
GO:0006351 transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0009880 embryonic pattern specification
GO:0010468 regulation of gene expression
GO:0032525 somite rostral/caudal axis specification
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060349 bone morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:3614797
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2WG77
PhosphoSite PhosphoSite-Q2WG77
TrEMBL
UniProt Splice Variant
Entrez Gene 622473
UniGene
RefSeq NP_001033004
MGI ID
MGI Symbol Ripply1
OMIM
CCDS CCDS30436
HPRD
IMGT
EMBL AB212222 AL672243
GenPept BAE53719 CAM46130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca