InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF6

Summary

InnateDB Protein

IDBP-17438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF6

Protein Name

ring finger protein (C3H2C3 type) 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370982

InnateDB Gene

IDBG-17430 (RNF6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269PubMed:19345326}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19345326}. Cytoplasm {ECO:0000269PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.

Disease Associations

Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269PubMed:12154016}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269PubMed:18368307, ECO:0000269PubMed:19345326}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030517	negative regulation of axon extension
GO:0044314	protein K27-linked ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070936	protein K48-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination