Version 5.4
Mus musculus Protein: Cldn2
Summary
InnateDB Protein IDBP-174403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn2
Protein Name claudin 2
Synonyms AL022813;
Species Mus musculus
Ensembl Protein ENSMUSP00000054219
InnateDB Gene IDBG-174401 (Cldn2)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000269PubMed:10508613}.
Subcellular Localization Cell junction, tight junction {ECO:0000269PubMed:11934881}. Cell membrane {ECO:0000269PubMed:11934881}; Multi-pass membrane protein {ECO:0000269PubMed:11934881}.
Disease Associations
Tissue Specificity Expressed in the kidney, liver and intestine, with higher levels in the ileum than in the jejunum. Low levels in the brain. {ECO:0000269PubMed:11934881, ECO:0000269PubMed:9647647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1276110
InterPro IPR003556 Claudin-14
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR005411 Claudin-2
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01589
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88552
PhosphoSite PhosphoSite-O88552
TrEMBL A3KGB5
UniProt Splice Variant
Entrez Gene 12738
UniGene Mm.485912
RefSeq NP_057884
MGI ID 3ZJ3
MGI Symbol Cldn2
OMIM
CCDS CCDS30437
HPRD
IMGT
EMBL AF072128 AK004990 AL672243 BC015252 BC085494
GenPept AAC27079 AAH15252 AAH85494 BAB23725

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca