InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdrd12

Summary

InnateDB Protein

IDBP-174420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdrd12

Protein Name

tudor domain containing 12

Synonyms

2410004F06Rik; 2410070K17Rik; ECAT8; EG434165; G1-476-14; repro23;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032701

InnateDB Gene

IDBG-174418 (Tdrd12)

Protein Structure

UniProt Annotation

Function

Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. {ECO:0000269PubMed:24067652}.

Subcellular Localization

Disease Associations

Tissue Specificity

Restricted to the gonads. {ECO:0000269PubMed:12787504, ECO:0000269PubMed:24067652}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0007140	male meiosis
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA
GO:0034587	piRNA metabolic process
GO:0043046	DNA methylation involved in gamete generation