InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scara5

Summary

InnateDB Protein

IDBP-174431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scara5

Protein Name

scavenger receptor class A, member 5 (putative)

Synonyms

4932433F15Rik; 4933425F03Rik; AV278087; Tesr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022610

InnateDB Gene

IDBG-174429 (Scara5)

Protein Structure

UniProt Annotation

Function

Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). {ECO:0000269PubMed:19154717}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19154717}; Single-pass type II membrane protein {ECO:0000269PubMed:19154717}.

Disease Associations

Tissue Specificity

Expressed in the testis, trachea, lung, bladder and small intestine; especially in epithelial cells associated with mucosal surfaces. {ECO:0000269PubMed:16407294}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0070287	ferritin receptor activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0010468	regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0034605	cellular response to heat
GO:0034755	iron ion transmembrane transport
GO:0070207	protein homotrimerization