InnateDB Protein
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IDBP-174433.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scara5
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Protein Name
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scavenger receptor class A, member 5 (putative)
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Synonyms
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4932433F15Rik; 4933425F03Rik; AV278087; Tesr;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000063391
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InnateDB Gene
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IDBG-174429 (Scara5)
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Protein Structure
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Function |
Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). {ECO:0000269PubMed:19154717}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:19154717}; Single-pass type II membrane protein {ECO:0000269PubMed:19154717}.
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Disease Associations |
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Tissue Specificity |
Expressed in the testis, trachea, lung, bladder and small intestine; especially in epithelial cells associated with mucosal surfaces. {ECO:0000269PubMed:16407294}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1918395
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InterPro |
IPR008160
Collagen triple helix repeat
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PFAM |
PF01391
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K299
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
71145
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UniGene |
Mm.83840
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RefSeq |
NP_001161790
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MGI ID |
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MGI Symbol |
Scara5
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OMIM |
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CCDS |
CCDS49523
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HPRD |
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IMGT |
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EMBL |
AK016543
AK016912
AK033154
AK133176
BC016096
BC023907
BC026758
BC032159
DQ122126
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GenPept |
AAH16096
AAH23907
AAH26758
AAH32159
AAZ41380
BAB30293
BAB30492
BAC28173
BAE21542
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