Version 5.4
Mus musculus Protein: Rgs9bp
Summary
InnateDB Protein IDBP-174546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs9bp
Protein Name regulator of G-protein signalling 9 binding protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000065511
InnateDB Gene IDBG-174544 (Rgs9bp)
Protein Structure
UniProt Annotation
Function Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation. {ECO:0000269PubMed:12560335, ECO:0000269PubMed:14625292, ECO:0000269PubMed:16908407, ECO:0000269PubMed:16939221}.
Subcellular Localization Membrane {ECO:0000269PubMed:12119397}; Single-pass type IV membrane protein {ECO:0000269PubMed:12119397}.
Disease Associations
Tissue Specificity Predominantly expressed in photoreceptors of the retina. Weakly expressed in other areas of the central nervous system. {ECO:0000269PubMed:12119397, ECO:0000269PubMed:14664818}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009968 negative regulation of signal transduction
GO:0050908 detection of light stimulus involved in visual perception
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2384418
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q148R9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 243923
UniGene Mm.431826
RefSeq NP_665839
MGI ID
MGI Symbol Rgs9bp
OMIM
CCDS CCDS21153
HPRD
IMGT
EMBL AF483907 AY229888 BC118006
GenPept AAI18007 AAM76160 AAP55847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca