Version 5.4
Homo sapiens Protein: SLC10A4
Summary
InnateDB Protein IDBP-17464.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC10A4
Protein Name solute carrier family 10 (sodium/bile acid cotransporter family), member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000273861
InnateDB Gene IDBG-17460 (SLC10A4)
Protein Structure
UniProt Annotation
Function Transporter for bile acids. {ECO:0000269PubMed:23589386}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:23589386}; Multi-pass membrane protein {ECO:0000269PubMed:23589386}.
Disease Associations
Tissue Specificity Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus. {ECO:0000269PubMed:18355966}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008508 bile acid:sodium symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0015721 bile acid and bile salt transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002657 Bile acid:sodium symporter
PFAM PF01758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EP9
PhosphoSite PhosphoSite-Q96EP9
TrEMBL
UniProt Splice Variant
Entrez Gene 201780
UniGene Hs.132591
RefSeq NP_689892
HUGO HGNC:22980
OMIM
CCDS CCDS3482
HPRD 11562
IMGT
EMBL AY704414 BC012048 BC019066
GenPept AAH12048 AAH19066 AAW30130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca