InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAG4

Summary

InnateDB Protein

IDBP-17467.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG4

Protein Name

BCL2-associated athanogene 4

Synonyms

BAG-4; SODD;

Species

Homo sapiens

Ensembl Protein

ENSP00000287322

InnateDB Gene

IDBG-17465 (BAG4)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria. {ECO:0000250, ECO:0000269PubMed:24270810}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0010763	positive regulation of fibroblast migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072659	protein localization to plasma membrane
GO:0090367	negative regulation of mRNA modification
GO:0097178	ruffle assembly
GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity