Version 5.4
Mus musculus Protein: Anp32a
Summary
InnateDB Protein IDBP-174683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anp32a
Protein Name acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Synonyms Anp32; I1PP2A; LANP; PHAP1; pp32; W91701;
Species Mus musculus
Ensembl Protein ENSMUSP00000082652
InnateDB Gene IDBG-174681 (Anp32a)
Protein Structure
UniProt Annotation
Function Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269PubMed:17557114}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12807913}. Cytoplasm {ECO:0000269PubMed:12807913}. Endoplasmic reticulum {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis.
Disease Associations
Tissue Specificity Predominantly expressed in the cerebellum. Expressed also in cortex, lung, skeletal muscle, gastrointestinal tract, spleen, liver and heart. {ECO:0000269PubMed:15895553}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016363 nuclear matrix
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:108447
InterPro IPR001611 Leucine-rich repeat
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35381
PhosphoSite PhosphoSite-O35381
TrEMBL
UniProt Splice Variant
Entrez Gene 11737
UniGene Mm.471284
RefSeq NP_033802
MGI ID 2JQD
MGI Symbol Anp32a
OMIM
CCDS CCDS40663
HPRD
IMGT
EMBL AF022957 BC062899 U73478
GenPept AAB39707 AAB91546 AAH62899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca